EXTRACELLULAR VESICLES FROM ADIPOSE-DERIVED STEM CELLS PROMOTE MICROGLIA M2 POLARIZATION AND NEUROLOGICAL RECOVERY IN A MOUSE MODEL OF TRANSIENT MIDDLE CEREBRAL ARTERY OCCLUSION

Abstract Background Adipose-derived stem cells (ADSCs) and their extracellular vesicles (EVs) have therapeutic potential in ischemic brain injury, but the underlying mechanism is poorly understood.The current study aimed to explore the contribution of miRNAs in Cooktop Knob ADSC-EVs to the treatment of cerebral ischemia.Methods After the intravenou

There is a growing interest in low dose radiation (LDR) to counteract neurodegeneration.However, LDR effects on normal brain have not been completely explored yet.Recent analyses showed that LDR exposure to normal brain tissue causes expression level changes of different proteins including neurodegeneration-associated proteins.We assessed the prote

BACKGROUND: Wildlife populations are difficult to monitor directly because of costs and logistical challenges associated with collecting informative abundance data from live animals.By contrast, data on harvested individuals (e.g., age and sex) are often readily available.Increasingly, integrated population models are used for natural resource mana

All economic activities have main and secondary effects.The main effects determine the economic position of the economic activity and constitute the purpose and motivation of the economic firms.But the secondary effects in the economic literature are known as external effects, and they are divided into two types of negative and positive effects.Cap

Propyl-propanethiosulfinate (PTS) is a component of Allium essential oils.This organosulfur molecule can be used as a feed additive to decrease the appearance of bacterial resistances caused by the residues of antibiotics.In previous in vitro genotoxicity studies, contradictory results were reported for PTS.In this Quilted Bodywarmers work, the in